If cocaine is consumed on its own, it yields two principal metabolites, ecgonine methyl ester and benzoyleconine. Neither compound has any discernible psychoactive effect. Cocaine co-administered with alcohol, however, yields a potent psychoactive metabolite, cocaethylene. Cocaethylene is very rewarding agent in its own right. It blocks the dopamine transporter and induces euphoria. Hence coca wine drinkers are effectively consuming three reinforcing drugs rather than one.
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